Recommend FreeBSD email setups?

Just wondering what the recommended setup for mail is for a FreeBSD system.

The two I've looked at so far(Qmail, postfix) both seem to have shortcomings.

QMail is a beast to configure and maintain since it isn't installed only with ports

postfix you can run with nothing but ports, but some of it's support tools (postfixadmin) seem tied to mysql, which virtualmin doesn't support.

Am I missing anything or perhaps I'm offbase on some of these assumptions?