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Usermin webmail is slow when opening an email with a large attachment. For an email with a 1 MB attachment there is a slight delay (tens of seconds) but opening a larger attachment, e.g. 15 MB, can take ages - looking at the miniserv.pl process it is using 100% CPU and has been going for > 25mins.
This looks related to nobody's post here: https://www.virtualmin.com/node/25554
From the web page titles, the following versions are installed: Virtualmin 4.11.gpl Usermin 1.600
UPDATE: It took ~38mins to finish.